Personalized 'Organ on a chip' Systems
‘Organ on a chip’ systems are microfluidic 3D human tissue and organ models designed to mimic the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a platform for personalized medicine and drug screening. Numerous animals die in traditional clinical trials, in addition, the studies last for 10-15 years and the average cost of developing a drug can exceed 2 billion dollars. Therefore, it is expected that these in vitro models will mimic the biomimetic compositions, architectures and functions and will close the large gap between the animal models and the human body. Our work in this field continues with the innovative projects.
Microfluidic Biosensor for Toxin Detection
The amount of toxin in marine wildlife and even marine birds and mammals has increased due to the increase in pollution in sea water. In this respect, our research group aim is to develop a relatively inexpensive, easy-to-use system that analyzes toxin substances in marine organisms with the microfluidic-biosensor system. Thus, the necessary controls will be made with the detection of target toxins in the frequently consumed seafood and the necessary measures will be taken by monitoring the marine pollution in this sense.
Plant Extract on a Chip
Like all living organisms, plants have their own defense systems by using various molecules. These molecules are bioactive and stable and can have antimicrobial and anticancer properties for human health benefits. Recent advancements in the extraction methods of target molecules make them an intriguing prospect for a novel drug development and disease treatment perspectives. Our research team is working on separating target molecules from the plants extract and investigating their anti-cancer properties. Current techniques for separation and screening of these molecules in the plants are expensive and time-consuming. One of our goals in this study is to design and use a microfluidic chip, to separate target molecules more quickly and cost-efficient manner. Afterward, investigate preliminary anticancer activity in addition to other medicinal properties.
Functional High Performance Polymeric Fibers (HiPER)
By an innovative two-step post-processing improvement during the melt-spinning process, we are able to selectively tune mechanics, diameter, morphology, and functionality like adhesion and flame retardancy. The fibers are passed through a first post-processing stage which has low temperature with low viscosity. In the second step, the fibers are faced by higher temperature and higher viscosity to manipulate desired functionalities.
For more information, click here.
Controlled Drug Delivery Systems
Our research team is working on core-shell nanofibers with different morphologies. Since the produced nanofibers are double-layered and the polymer shell layer is modified as porous and non-porous, the delivery of the drug, bioactive agents, additives, protein, growth factor, and etc. can be controlled over a prolonged period of time. Various studies have been carried out by our research group in medical applications where burst or prolonged drug release is necessary from antibacterial to wound healing, prolonged insulin release for diabetic patients avoiding frequently insulin intake and blood glucose measurement; the control and prevention of periodontal defects with controlled release.